|
KMID : 0606320040200010006
|
|
Journal of Phamacetical Sciences Sookmyung Women s University
2004 Volume.20 No. 1 p.6 ~ p.9
|
|
|
Effects of Selenium on the carbon clearance activity of macrophage in mice
|
|
Choi Ji-Sun
Pyo Myoung-Yun
|
|
|
Abstract
|
|
|
|
Effects of Selenium (Se) on the carbon clearance activity of macrophage in blood were investigated in mice. Se was orally administered in drinking water for 18 days (1ppm or 3ppm) or intraperioneally with a single dose of 0.05, 0.25, 0.5 mg/kg b.w. to normal and CY-treated ICR mice. Cyclophosphamide (CY) was injected I.p. to mice with a single dose of 20 mg/kg b.w. on the last day of Se-administration. Carbon suspension was injected I.v. at 0.01ml/g b.w. in mice 48 hrs after the administration of experimental chemicals. Blood was collected from retro-orbital venous plexus of mice 5 min, 10 min after injection of carbon suspension and carbon clearance (t1/2, min) was assessed. The treatment of Se alone slightly increased carbon clearance activity of circulating macrophage when compared with control group. Carbon clearance activity was significantly enhanced in Se plus CY when compared with the treatment of CY alone. These results indicate that Se seemed to significantly restore the reduction of phagocytic activity induced by CY.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|